Chromosome 10
Chromosome 10
Length of DNA
133'797'422 bp
i.e. 4.5 cm
Estimated number of genes
730
Sequenced
in Germany, Greece, the UK and the USA
Link
Gene…Ethics
Emily has been depressed for months now. Her doctor has prescribed medication, but it is not helping her. So he has suggested she does a DNA test. Why? To find a treatment more adapted to her body.
lowers sound and vision
PCDH15: Gene associated with congenital deafness and blindness.
External links
Corresponding protein in UniProtKB/Swiss-Prot
Delayed
CASP7 : this protein called caspase is engaged in repairing self-inflicted holes in a cell’s membrane so that the cell has time to prepare a ‘cleaner’ programmed cell death, that is to say without being detrimental to the environment.
On a tightrope
AIFM2: this gene codes for a protein that removes excess iron, which can be toxic to cells (ferroptosis).
molecular degradation
CYP2E1: This gene plays an important role in alcohol degradation and the detoxication of substances such as paracetamol.
insulin resistance
TCF7L2: Gene involved in the development of type 2 diabetes.
External links
Corresponding protein in UniProtKB/Swiss-Prot
learning
EIF4EBP2: Gene coding for a protein involved in synaptic plasticity, learning and memory formation. The protein is known as a ‘disordered’ protein and its lack of stability gives rise to a new kind of biological regulation.
External links
Protein Spotlight : a question of perspective
Corresponding protein in UniProtKB/Swiss-Prot
tenacious memory
CPEB3: Gene coding for a protein involved in enhancing learning and memory performance. This protein has prion-like properties.
Internal links
Chromosome 20: Prions: two-faced proteinsthe contours of heredity
MKI67: Gene coding for a protein which is important in maintaining the well-known shape of packed chromosomes.
External links
Protein Spotlight : the contours of heredity
Corresponding protein in UniProtKB/Swiss-Prot
headache?
KCNK18: This gene could be involved in migraine.
hibernation
PNLIP: This gene codes for a protein which is involved in the digestion of fats, and plays an important role in animals that hibernate.
noonan
SHOC2: This gene is associated with Noonan syndrome, whose symptoms are developmental delays and hair loss.
External links
Protein Spotlight: The matchmaker
Corresponding disease in OMIM
Corresponding protein in UniProtKB/Swiss-Prot
Internal links
Bioinformatics expert: Noonan syndrome in the OMIM database
our body’s timekeeper
OPN4: This gene is involved in synchronizing our biological rhythms with the alternation of day and night.
External links
Corresponding protein in UniProtKB/Swiss-Prot
little holes
PRF1: This genes codes for perforin, a protein which is able to make holes in cell membranes, thus playing an important role in the destruction of defective cells.
External links
Protein Spotlight: Our hollow architecture
Corresponding protein in UniProtKB/Swiss-Prot
defence
DCLRE1C: This gene codes for the artemis protein which is involved in antibody production.
External links
Corresponding protein in UniProtKB/Swiss-Prot
spotless cells
PITRM1: This gene codes for a protein involved in cleaning cells.