The human genome was sequenced in 2000. The news broke as though we had just unravelled the mystery of human life. Yet, we still know very little.
AS3MT: gene coding for a protein that modifies arsenic and makes it less toxic. Adaptation to arsenic serves as a model for how organisms evolve to survive under toxic conditions.
Corresponding protein in UniProtKB/Swiss-Prot
APOBEC3G: Gene involved in antiviral defense.
CYB5R3: gene coding for a protein that is involved in the redox of iron atoms in hemoglobin. Variations in this gene are associated with hemoglobin that binds oxygen less efficiently. Carriers have bluish (cyanotic) skin.
Corresponding protein in UniProtKB/Swiss-Prot
SHANK3: This gene is associated with autism.
CYP2D6: This gene is involved in neutralising toxic products and certain drugs.
Corresponding protein in UniProtKB/Swiss-Prot
TEF: This gene may be involved in epilepsy. The gene was discovered by the cleaning staff while vacuuming the animal care facilities at the University of Geneva!
Prolune - snapshot: The PAR bZIP family
MB: This gene is involved in oxygen transport in our muscles.
Chromosome 11: HBB
CRYBA4/CRYBB2: These genes are involved in the lens structure of our eyes.
Corresponding protein in UniProtKB/Swiss-Prot
RTN4R: This gene hinders neuronal growth and helps them to branch out.
Protein Spotlight: Nerve regrowth: nipped by a no-go
Corresponding protein in UniProtKB/Swiss-Prot