One of the strengths of bioinformatics is to predict. In particular, computer programs are able to reveal the existence of a gene on a chromosome or a protein’s structure. But bioinformatics has its limits. Here is the story of ghrelin and obestatin, two proteins which play a key role in the regulation of our appetite.
HMCES: This gene codes for a protein which preserves genome integrity by promoting error-free repair during DNA replication.
LZTFL1 : a variant in this gene is associated with higher susceptibility to respiratory failure among COVID-19 patients (Caucasians (only).
Corresponding protein in UniProtKB/Swiss-Prot
A gene cluster (50’000 bp) which was inherited about 40,000 to 60,000 years ago from Neanderthals and is associated with a major genetic risk for respiratory failure upon SARS-CoV-2 infection.
SETMAR: A gene that humans and apes probably acquired from a marine organism some tens of millions of years ago. It codes for a protein which plays an important role in the integrity of our genome.
CCR5: This gene codes for a receptor to cytokine. Certain versions of this gene are associated with resistance to AIDS virus infection.
Prolune - snapshot: PSC-RANTES proteinCorresponding protein in UniProtKB/Swiss-Prot
RHO: This gene is involved in night vision.
Protein Spotlight: Proteic graceCorresponding protein in UniProtKB/Swiss-Prot
CRBN: This gene codes for a protein which is involved in brain, blood vessel and limb development. This protein can bind to thalidomide, a drug which was prescribed to pregnant women in the late 1950s.
Protein Spotlight: A short storyCorresponding protein in UniProtKB/Swiss-Prot