Chromosome 13
Chromosome 13
Length of DNA
114'364'328 bp
i.e. 3.8 cm
Estimated number of genes
321
Sequenced
in the UK
Link
A taste of happiness
For many, chocolate offers brief moments of pleasure that we like to enjoy over and over again. Why?
haemophilia
F10: This gene is important in blood coagulation. Some variations are associated with certain forms of haemophilia.
External links
Corresponding protein in UniProtKB/Swiss-Prot
Connection, deafness and mosquitoes
GJB2: gene encoding protein that connects cells to each other and allows the diffusion of small molecules and ions from one cell to another. Variations in this gene are the cause of certain forms of deafness. One of these variations could also be associated with thicker skin, potentially offering greater protection against mosquito bites and, consequently, malaria. This hypothesis remains to be confirmed.
External links
Corresponding protein in UniProtKB/Swiss-Prot Protein Spotlight: Sound and silence Publication: Age Estimate of GJB2-p.(Arg143Trp) Founder Variant in Hearing Impairment in Ghana, Suggests Multiple Independent Origins across Populationspolymers
ACOD1: this gene codes for a protein that catalyzes the production of itaconate. Itaconate is widely used in the synthesis of polymers to make lubricants, thickeners, rubber or resins. Itaconate is also involved in the inhibition of inflammatory response and in antimicrobial response.
turn it down
GJB2: gene encoding protein that connects cells to each other and allows the diffusion of small molecules and ions from one cell to another. Variations in this gene are the cause of certain forms of deafness. One of these variations could also be associated with thicker skin, potentially offering greater protection against mosquito bites and, consequently, malaria. This hypothesis remains to be confirmed.
External links
Corresponding protein in UniProtKB/Swiss-Prot
out of the ordinary
SLITRK1: Gene involved in neuronal dendrite outgrowth. Variations in this gene are associated with Tourette Syndrome, a neurological disorder.
defence
TNFSF13B: This gene codes for a cytokine, an important molecule in the immune response.
External links
Corresponding protein in UniProtKB/Swiss-Prot
don’t worry, be happy…
DAOA: This gene is involved in producing a molecule which interacts with the ‘happy receptor’. This part of the chromosome is associated with psychiatric disorders such as schizophrenia.
External links
Corresponding protein in UniProtKB/Swiss-Prot
a taxi for copper
ATO7B: This gene is involved in copper transport, and is essential for the correct functioning of many enzymes.
External links
Corresponding protein in UniProtKB/Swiss-Prot
a longer life
KL: This gene codes for the klotho protein which seems to be involved in longevity. Injection of this protein into aged monkeys seems to enhance cognition.
External links
Protein Spotlight: The thread of life
Corresponding protein in UniProtKB/Swiss-Prot
Publication: Longevity factor klotho enhances cognition in aged nonhuman primates (2023)
cellular abundance
BRCA2: Gene coding for a protein involved in DNA repair. Certain variations in this gene are associated with breast cancer.
External links
Corresponding protein in UniProtKB/Swiss-Prot