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82
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7
|

The human genome odyssey
Imagine a very long text written by using only 4 letters: A, T, G and C. Three billion of these letters – spread over 23 chromosomes – are linked to one another to form our genome. This is what constitutes our DNA, our biological identity and the genetic heritage that we pass on to our children.
a sixth sense?
VN1R5: This gene codes for a pheromone receptor.
External links
Protein Spotlight: No one nose
contraception
BRDT : This gene is involved in making sperm. It is an ideal target for male contraception.
External links
Protein Spotlight : asking life to be patient
ramifications
SRGAP2 : This gene is involved in brain development. It is only found in humans.
External links
Protein Spotlight : branching out
bad smell
FMO3 : When defective, this gene is involved in the release of bad body smells (rotting fish).
External links
Protein Spotlight : a case for discomfort
geometry
TRNP1: This gene is involved in brain development and the formation of grooves.
External links
Protein Spotlight : the geometry of intelligence
eternal youth…
KISS1: If this gene is dysfunctional, puberty stalls. A way of staying young?
External links
Protein Spotlight: Tintin’s blight
duffy
DARC: This gene codes for the Duffy blood group antigens. Individuals who do not produce the Duffy FY(A-B-) antigen are more resistant to certain forms of malaria.
External links
Bioinformatics expert : DARC in the OMIM database
headache?
COX2: This gene codes for a protein which is targeted by aspirin.
External links
3D story (PDB): Cyclooxygenase
taxi for fat
ApoAII: This gene is involved in the transport of fats in our blood.
External links
Bioinformatics expert: the ApoAII protein in the presence of lipids, in the PDB databank (click on ‘View in 3D’)
Internal links
Chromosome 19: ApoE
healing
CRP: This gene codes for a protein which induces tissue repair.
External links
Protein Spotlight: No more Christmas pudding?
chromosome scaffolding
HIST2H4A: This is one of the numerous genes that code for histone proteins. The characteristic architecture of a chromosome is due to the way DNA is wound around histones.
External links
Bioinformatics expert: DNA wound around histones in the PDB database (click on ‘View in 3D’)
Internal links
Chromosome 6: HIST1H4
a painful story
PDE4B: This gene may be involved in the action of certain kinds of medication (antidepressants, anti-inflammatory drugs).
External links
Prolune - snapshot: Beta-arrestin 2 and pde4
boy or girl?
RSPO1: Gene involved in gender determination.
External links
Prolune - article: ♂ or ♀, that is the question
the effects of cannabis
CNR2: This gene codes for a receptor which binds to one of the components of cannabis.
External links
Prolune - snapshot: Cannabinoid receptor 2 protein
sweet
TAR1S1/ TAR1S2/ TAR1S3: Groups of genes involved in the perception of sweet and umami tastes.